Reaction Details Report a problem with these data
Target
4-hydroxyphenylpyruvate dioxygenase
Ligand
BDBM50264378
Substrate
n/a
Meas. Tech.
ChEMBL_1698557 (CHEMBL4049539)
Kd
6.0±n/a nM
Citation
 Santucci, A; Bernardini, G; Braconi, D; Petricci, E; Manetti, F 4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases. J Med Chem 60:4101-4125 (2017) [PubMed]  Article 
Target
Name:
4-hydroxyphenylpyruvate dioxygenase
Synonyms:
1.13.11.27 | 4-hydroxyphenylpyruvate dioxygenase | 4-hydroxyphenylpyruvic acid oxidase | 4HPPD | HPD | HPPD_DAUCA | HPPDase
Type:
PROTEIN
Mol. Mass.:
48138.57
Organism:
Daucus carota
Description:
ChEMBL_117486
Residue:
442
Sequence:
MGKKQSEAEILSSNSSNTSPATFKLVGFNNFVRANPKSDHFAVKRFHHIEFWCGDATNTSRRFSWGLGMPLVAKSDLSTGNSVHASYLVRSANLSFVFTAPYSPSTTTSSGSAAIPSFSASGFHSFAAKHGLAVRAIALEVADVAAAFEASVARGARPASAPVELDDQAWLAEVELYGDVVLRFVSFGREEGLFLPGFEAVEGTASFPDLDYGIRRLDHAVGNVTELGPVVEYIKGFTGFHEFAEFTAEDVGTLESGLNSVVLANNEEMVLLPLNEPVYGTKRKSQIQTYLEHNEGAGVQHLALVSEDIFRTLREMRKRSCLGGFEFMPSPPPTYYKNLKNRVGDVLSDEQIKECEDLGILVDRDDQGTLLQIFTKPVGDRPTLFIEIIQRVGCMLKDDAGQMYQKGGCGGFGKGNFSELFKSIEEYEKTLEAKQITGSAAA
  
Inhibitor
Name:
BDBM50264378
Synonyms:
CHEMBL4098026
Type:
Small organic molecule
Emp. Form.:
C15H12F3NO4S
Mol. Mass.:
359.32
SMILES:
CS(=O)(=O)c1cc(ccc1C(=O)C(C#N)C(=O)C1CC1)C(F)(F)F
Structure:
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