Reaction Details Report a problem with these data
Target
COP9 signalosome complex subunit 5
Ligand
BDBM50264424
Substrate
n/a
Meas. Tech.
ChEMBL_1698724 (CHEMBL4049706)
IC50
15300±n/a nM
Citation
 Perez, C; Li, J; Parlati, F; Rouffet, M; Ma, Y; Mackinnon, AL; Chou, TF; Deshaies, RJ; Cohen, SM Discovery of an Inhibitor of the Proteasome Subunit Rpn11. J Med Chem 60:1343-1361 (2017) [PubMed]  Article 
Target
Name:
COP9 signalosome complex subunit 5
Synonyms:
COP9 signalosome complex subunit 5 (Csn5) | COPS5 | CSN5 | CSN5_HUMAN | JAB1
Type:
Protein
Mol. Mass.:
37578.39
Organism:
Homo sapiens (Human)
Description:
Q92905
Residue:
334
Sequence:
MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS
  
Inhibitor
Name:
BDBM50264424
Synonyms:
CHEMBL4078891
Type:
Small organic molecule
Emp. Form.:
C20H14N4O2S2
Mol. Mass.:
406.481
SMILES:
NC(=O)c1cnc2c(SSc3cccc4cc(cnc34)C(N)=O)cccc2c1
Structure:
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