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Target
Adenosine receptor A2a
Ligand
BDBM50266652
Substrate
n/a
Meas. Tech.
ChEMBL_1701169 (CHEMBL4052151)
EC50
2.9±n/a nM
Citation
 Petrelli, R; Scortichini, M; Kachler, S; Boccella, S; Cerchia, C; Torquati, I; Del Bello, F; Salvemini, D; Novellino, E; Luongo, L; Maione, S; Jacobson, KA; Lavecchia, A; Klotz, KN; Cappellacci, L Exploring the Role of N J Med Chem 60:4327-4341 (2017) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50266652
Synonyms:
CHEMBL4078479
Type:
Small organic molecule
Emp. Form.:
C19H20IN9O3
Mol. Mass.:
549.3251
SMILES:
CCn1nnc(n1)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)ncnc12 |r|
Structure:
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