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Target
Protein Mdm4
Ligand
BDBM50266870
Substrate
n/a
Meas. Tech.
ChEMBL_1701466 (CHEMBL4052448)
Ki
12400±n/a nM
Citation
 Twarda-Clapa, A; Krzanik, S; Kubica, K; Guzik, K; Labuzek, B; Neochoritis, CG; Khoury, K; Kowalska, K; Czub, M; Dubin, G; Dömling, A; Skalniak, L; Holak, TA 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem 60:4234-4244 (2017) [PubMed]  Article 
Target
Name:
Protein Mdm4
Synonyms:
Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:
Oncoprotein
Mol. Mass.:
54842.04
Organism:
Homo sapiens (Human)
Description:
The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:
490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
  
Inhibitor
Name:
BDBM50266870
Synonyms:
CHEMBL4104110
Type:
Small organic molecule
Emp. Form.:
C31H25Cl2FN4O5
Mol. Mass.:
623.458
SMILES:
OC(=O)CCC(=O)NCCOC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(Cl)cc1)-c1ccc(F)cc1 |(13.19,-25.49,;13.93,-24.13,;13.12,-22.82,;15.47,-24.08,;16.2,-22.73,;15.39,-21.42,;13.85,-21.46,;16.12,-20.07,;17.66,-20.02,;18.39,-18.66,;19.93,-18.61,;20.66,-17.26,;19.85,-15.95,;22.2,-17.21,;23.14,-18.43,;24.59,-17.92,;25.95,-18.64,;27.26,-17.84,;28.62,-18.56,;27.22,-16.3,;25.86,-15.56,;24.55,-16.38,;23.07,-15.95,;22.55,-14.49,;23.42,-13.22,;22.48,-12,;21.03,-12.52,;21.07,-14.06,;19.85,-15,;18.43,-14.42,;17.21,-15.36,;15.78,-14.77,;15.58,-13.25,;14.15,-12.66,;16.8,-12.3,;18.22,-12.89,;24.96,-13.18,;25.69,-11.82,;27.23,-11.78,;28.04,-13.09,;29.58,-13.04,;27.3,-14.44,;25.77,-14.49,)|
Structure:
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