Reaction Details Report a problem with these data
Target
Protein Mdm4
Ligand
BDBM50266882
Substrate
n/a
Meas. Tech.
ChEMBL_1701466 (CHEMBL4052448)
Ki
9750±n/a nM
Citation
 Twarda-Clapa, A; Krzanik, S; Kubica, K; Guzik, K; Labuzek, B; Neochoritis, CG; Khoury, K; Kowalska, K; Czub, M; Dubin, G; Dömling, A; Skalniak, L; Holak, TA 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem 60:4234-4244 (2017) [PubMed]  Article 
Target
Name:
Protein Mdm4
Synonyms:
Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:
Oncoprotein
Mol. Mass.:
54842.04
Organism:
Homo sapiens (Human)
Description:
The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:
490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
  
Inhibitor
Name:
BDBM50266882
Synonyms:
CHEMBL4085272
Type:
Small organic molecule
Emp. Form.:
C35H32Cl2FN3O6
Mol. Mass.:
680.549
SMILES:
OC(=O)CCC(=O)OCCCCCCOC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(Cl)cc1)-c1ccc(F)cc1 |(11.56,-10.6,;12.33,-11.94,;11.56,-13.27,;13.87,-11.94,;14.64,-13.27,;16.18,-13.27,;16.95,-11.94,;16.95,-14.6,;18.49,-14.6,;19.26,-15.94,;20.8,-15.94,;21.57,-17.27,;23.11,-17.27,;23.88,-18.6,;25.42,-18.6,;26.19,-17.27,;25.42,-15.94,;27.73,-17.27,;28.64,-18.52,;30.1,-18.04,;31.43,-18.81,;32.77,-18.04,;34.1,-18.81,;32.77,-16.5,;31.43,-15.73,;30.1,-16.5,;28.64,-16.02,;28.16,-14.56,;29.06,-13.31,;28.16,-12.07,;26.69,-12.54,;26.69,-14.08,;25.45,-14.98,;24.04,-14.36,;22.8,-15.27,;21.39,-14.64,;21.23,-13.11,;19.82,-12.48,;22.48,-12.2,;23.88,-12.83,;30.6,-13.31,;31.37,-11.98,;32.91,-11.98,;33.68,-13.31,;35.22,-13.31,;32.91,-14.65,;31.37,-14.65,)|
Structure:
Search PDB for entries with ligand similarity: