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Target
Protein Mdm4
Ligand
BDBM50266902
Substrate
n/a
Meas. Tech.
ChEMBL_1701466 (CHEMBL4052448)
Ki
6760±n/a nM
Citation
 Twarda-Clapa, A; Krzanik, S; Kubica, K; Guzik, K; Labuzek, B; Neochoritis, CG; Khoury, K; Kowalska, K; Czub, M; Dubin, G; Dömling, A; Skalniak, L; Holak, TA 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem 60:4234-4244 (2017) [PubMed]  Article 
Target
Name:
Protein Mdm4
Synonyms:
Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:
Oncoprotein
Mol. Mass.:
54842.04
Organism:
Homo sapiens (Human)
Description:
The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:
490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
  
Inhibitor
Name:
BDBM50266902
Synonyms:
CHEMBL4104786
Type:
Small organic molecule
Emp. Form.:
C32H21Cl3FN3O3
Mol. Mass.:
620.885
SMILES:
OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(OCc2ccc(Cl)c(Cl)c2)cc1)-c1ccc(F)cc1 |(20.17,-21.62,;20.94,-20.3,;20.17,-18.95,;22.48,-20.3,;23.38,-21.55,;24.85,-21.05,;26.19,-21.82,;27.53,-21.05,;28.85,-21.82,;27.52,-19.51,;26.19,-18.74,;24.85,-19.52,;23.38,-19.04,;22.9,-17.58,;23.81,-16.34,;22.91,-15.09,;21.44,-15.57,;21.44,-17.11,;20.19,-18.02,;18.79,-17.39,;18.63,-15.87,;17.22,-15.24,;15.97,-16.14,;14.57,-15.52,;13.32,-16.43,;11.91,-15.8,;10.68,-16.71,;9.27,-16.09,;9.1,-14.55,;7.69,-13.93,;10.35,-13.64,;10.19,-12.11,;11.76,-14.27,;16.14,-17.68,;17.54,-18.3,;25.35,-16.34,;26.11,-17.68,;27.65,-17.68,;28.43,-16.35,;29.97,-16.35,;27.66,-15.02,;26.12,-15.01,)|
Structure:
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