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Target
Protein Mdm4
Ligand
BDBM50266895
Substrate
n/a
Meas. Tech.
ChEMBL_1701466 (CHEMBL4052448)
Ki
4400±n/a nM
Citation
 Twarda-Clapa, A; Krzanik, S; Kubica, K; Guzik, K; Labuzek, B; Neochoritis, CG; Khoury, K; Kowalska, K; Czub, M; Dubin, G; Dömling, A; Skalniak, L; Holak, TA 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem 60:4234-4244 (2017) [PubMed]  Article 
Target
Name:
Protein Mdm4
Synonyms:
Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:
Oncoprotein
Mol. Mass.:
54842.04
Organism:
Homo sapiens (Human)
Description:
The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:
490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
  
Inhibitor
Name:
BDBM50266895
Synonyms:
CHEMBL4089364
Type:
Small organic molecule
Emp. Form.:
C32H21ClF3N3O3
Mol. Mass.:
587.976
SMILES:
OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(OCc2cc(F)cc(F)c2)cc1)-c1ccc(F)cc1 |(17.67,-17.78,;18.44,-16.46,;17.67,-15.11,;19.98,-16.46,;20.88,-17.71,;22.35,-17.21,;23.69,-17.98,;25.02,-17.21,;26.35,-17.98,;25.01,-15.66,;23.68,-14.9,;22.34,-15.68,;20.88,-15.2,;20.4,-13.73,;21.3,-12.5,;20.4,-11.25,;18.94,-11.72,;18.94,-13.27,;17.69,-14.18,;16.28,-13.55,;16.12,-12.02,;14.71,-11.4,;13.47,-12.3,;12.06,-11.68,;10.82,-12.58,;9.41,-11.96,;9.25,-10.43,;7.85,-9.8,;7.68,-8.27,;6.6,-10.71,;6.77,-12.25,;5.52,-13.16,;8.17,-12.87,;13.63,-13.84,;15.04,-14.46,;22.84,-12.5,;23.61,-13.84,;25.15,-13.84,;25.93,-12.51,;27.47,-12.51,;25.16,-11.17,;23.62,-11.17,)|
Structure:
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