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Target
Protein Mdm4
Ligand
BDBM50266896
Substrate
n/a
Meas. Tech.
ChEMBL_1701466 (CHEMBL4052448)
Ki
4710±n/a nM
Citation
 Twarda-Clapa, A; Krzanik, S; Kubica, K; Guzik, K; Labuzek, B; Neochoritis, CG; Khoury, K; Kowalska, K; Czub, M; Dubin, G; Dömling, A; Skalniak, L; Holak, TA 1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers. J Med Chem 60:4234-4244 (2017) [PubMed]  Article 
Target
Name:
Protein Mdm4
Synonyms:
Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4
Type:
Oncoprotein
Mol. Mass.:
54842.04
Organism:
Homo sapiens (Human)
Description:
The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose.
Residue:
490
Sequence:
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
  
Inhibitor
Name:
BDBM50266896
Synonyms:
CHEMBL4096099
Type:
Small organic molecule
Emp. Form.:
C32H20ClF4N3O3
Mol. Mass.:
605.966
SMILES:
OC(=O)c1[nH]c2cc(Cl)ccc2c1-c1c(ncn1Cc1ccc(OCc2cc(F)c(F)c(F)c2)cc1)-c1ccc(F)cc1 |(19.25,-22.18,;20.01,-20.86,;19.25,-19.51,;21.55,-20.86,;22.46,-22.11,;23.93,-21.61,;25.27,-22.38,;26.6,-21.61,;27.93,-22.38,;26.59,-20.06,;25.26,-19.3,;23.92,-20.08,;22.45,-19.6,;21.98,-18.14,;22.88,-16.9,;21.98,-15.65,;20.51,-16.13,;20.51,-17.67,;19.27,-18.58,;17.86,-17.95,;17.7,-16.43,;16.29,-15.8,;15.05,-16.7,;13.64,-16.08,;12.4,-16.99,;10.99,-16.36,;10.83,-14.83,;9.42,-14.2,;9.26,-12.67,;8.18,-15.11,;6.77,-14.49,;8.34,-16.65,;7.1,-17.56,;9.75,-17.27,;15.21,-18.24,;16.62,-18.86,;24.42,-16.9,;25.19,-18.24,;26.73,-18.24,;27.5,-16.91,;29.04,-16.91,;26.74,-15.58,;25.2,-15.57,)|
Structure:
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