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Target
TATA box-binding protein-associated factor RNA polymerase I subunit A
Ligand
BDBM50249797
Substrate
n/a
Meas. Tech.
ChEMBL_1701843 (CHEMBL4053076)
IC50
>20000±n/a nM
Citation
 Igoe, N; Bayle, ED; Fedorov, O; Tallant, C; Savitsky, P; Rogers, C; Owen, DR; Deb, G; Somervaille, TC; Andrews, DM; Jones, N; Cheasty, A; Ryder, H; Brennan, PE; Müller, S; Knapp, S; Fish, PV Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies. J Med Chem 60:668-680 (2017) [PubMed]  Article 
Target
Name:
TATA box-binding protein-associated factor RNA polymerase I subunit A
Synonyms:
RNA polymerase I-specific TBP-associated factor 48 kDa | TAF1A | TAF1A_HUMAN | TAFI48 | TATA box-binding protein-associated factor 1A | TATA box-binding protein-associated factor RNA polymerase I subunit A | TBP-associated factor 1A | Transcription factor SL1 | Transcription initiation factor SL1/TIF-IB subunit A
Type:
PROTEIN
Mol. Mass.:
52694.59
Organism:
Homo sapiens
Description:
ChEMBL_117487
Residue:
450
Sequence:
MSDFSEELKGPVTDDEEVETSVLSGAGMHFPWLQTYVETVAIGGKRRKDFAQTTSACLSFIQEALLKHQWQQAAEYMYSYFQTLEDSDSYKRQAAPEIIWKLGSEILFYHPKSNMESFNTFANRMKNIGVMNYLKISLQHALYLLHHGMLKDAKRNLSEAETWRHGENTSSREILINLIQAYKGLLQYYTWSEKKMELSKLDKDDYAYNAVAQDVFNHSWKTSANISALIKIPGVWDPFVKSYVEMLEFYGDRDGAQEVLTNYAYDEKFPSNPNAHIYLYNFLKRQKAPRSKLISVLKILYQIVPSHKLMLEFHTLLRKSEKEEHRKLGLEVLFGVLDFAGCTKNITAWKYLAKYLKNILMGNHLAWVQEEWNSRKNWWPGFHFSYFWAKSDWKEDTALACEKAFVAGLLLGKGCRYFRYILKQDHQILGKKIKRMKRSVKKYSIVNPRL
  
Inhibitor
Name:
BDBM50249797
Synonyms:
CHEMBL4059509
Type:
Small organic molecule
Emp. Form.:
C20H19N3O3S
Mol. Mass.:
381.448
SMILES:
CCc1cc2cc(NS(=O)(=O)c3ccc(cc3)C#N)ccc2n(CC)c1=O
Structure:
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