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Target
Gamma-aminobutyric acid receptor subunit gamma-1
Ligand
BDBM50011979
Substrate
n/a
Meas. Tech.
ChEBML_69892
Kd
72±n/a nM
Citation
 de Costa, BR; Lewin, AH; Rice, KC; Skolnick, P; Schoenheimer, JA Novel site-directed affinity ligands for GABA-gated chloride channels: synthesis, characterization, and molecular modeling of 1-(isothiocyanatophenyl)-4-tert-butyl-2,6,7-trioxabicyclo[2.2.2]octanes . J Med Chem 34:1531-8 (1991) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit gamma-1
Synonyms:
Benzodiazepine receptors | Benzodiazepine receptors; peripheral & central | GABA receptor gamma-1 subunit | GBRG1_RAT | Gabrg1
Type:
PROTEIN
Mol. Mass.:
53557.84
Organism:
Rattus norvegicus
Description:
ChEMBL_193817
Residue:
465
Sequence:
MGSGKVFLFSPSLLWSQTRGVRLIFLLLTLHLGNCIDKADDEDDEDLTMNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWSDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEISHTISGDYIIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNNKGKTTRDRKLKSKTSVSPGLHAGSTLIPMNNISMPQGEDDYGYQCLEGKDCATFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
  
Inhibitor
Name:
BDBM50011979
Synonyms:
4-tert-Butyl-1-(4-isothiocyanato-phenyl)-2,6,7-trioxa-bicyclo[2.2.2]octane | CHEMBL38835
Type:
Small organic molecule
Emp. Form.:
C16H19NO3S
Mol. Mass.:
305.392
SMILES:
CC(C)(C)C12COC(OC1)(OC2)c1ccc(cc1)N=C=S
Structure:
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