Reaction Details Report a problem with these data
Target
Basic phospholipase A2 VRV-PL-VIIIa
Ligand
BDBM50269108
Substrate
n/a
Meas. Tech.
ChEMBL_1705594 (CHEMBL4056827)
IC50
30101±n/a nM
Citation
 Lokeshwari, DM; Achutha, DK; Srinivasan, B; Shivalingegowda, N; Krishnappagowda, LN; Kariyappa, AK Synthesis of novel 2-pyrazoline analogues with potent anti-inflammatory effect mediated by inhibition of phospholipase A2: Crystallographic, in silico docking and QSAR analysis. Bioorg Med Chem Lett 27:3806-3811 (2017) [PubMed]  Article 
Target
Name:
Basic phospholipase A2 VRV-PL-VIIIa
Synonyms:
3.1.1.4 | Basic phospholipase A2 VRV-PL-VIIIa | DPLA2 | PA2B8_DABRR | PLA24 | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 4 | svPLA2
Type:
PROTEIN
Mol. Mass.:
13615.14
Organism:
Daboia russelii
Description:
ChEMBL_116772
Residue:
121
Sequence:
SLLEFGKMILEETGKLAIPSYSSYGCYCGWGGKGTPKDATDRCCFVHDCCYGNLPDCNPKSDRYKYKRVNGAIVCEKGTSCENRICECDKAAAICFRQNLNTYSKKYMLYPDFLCKGELKC
  
Inhibitor
Name:
BDBM50269108
Synonyms:
CHEMBL4102805
Type:
Small organic molecule
Emp. Form.:
C22H17Cl3N2O
Mol. Mass.:
431.742
SMILES:
COc1cccc(c1)C1=NN(C(C1)c1cccc(Cl)c1Cl)c1cccc(Cl)c1 |t:9|
Structure:
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