Reaction Details Report a problem with these data
Target
Kallikrein-1
Ligand
BDBM50013001
Substrate
n/a
Meas. Tech.
ChEBML_92229
IC50
11800±n/a nM
Citation
 McConnell, RM; Barnes, GE; Hoyng, CF; Gunn, JM New leupeptin analogues: synthesis and inhibition data. J Med Chem 33:86-93 (1990) [PubMed]  Article 
Target
Name:
Kallikrein-1
Synonyms:
KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein
Type:
Enzyme
Mol. Mass.:
28874.69
Organism:
Homo sapiens (Human)
Description:
P06870
Residue:
262
Sequence:
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
  
Inhibitor
Name:
BDBM50013001
Synonyms:
CHEMBL3143646 | {1-[1-(4-Amino-1-formyl-butylcarbamoyl)-3-methyl-butylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C28H38N4O5
Mol. Mass.:
510.6251
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCCN)C=O |r|
Structure:
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