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Target
Metallo-beta-lactamase type 2
Ligand
BDBM50270748
Substrate
n/a
Meas. Tech.
ChEMBL_1709503 (CHEMBL4119552)
Ki
11000±n/a nM
Citation
 McGeary, RP; Tan, DTC; Selleck, C; Monteiro Pedroso, M; Sidjabat, HE; Schenk, G Structure-activity relationship study and optimisation of 2-aminopyrrole-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile as a broad spectrum metallo-?-lactamase inhibitor. Eur J Med Chem 137:351-364 (2017) [PubMed]  Article 
Target
Name:
Metallo-beta-lactamase type 2
Synonyms:
BLAB_AERHY | Beta-lactamase | cphA
Type:
PROTEIN
Mol. Mass.:
28022.56
Organism:
Aeromonas hydrophila
Description:
ChEMBL_641771
Residue:
254
Sequence:
MMKGWMKCGLAGAVVLMASFWGGSVRAAGMSLTQVSGPVYVVEDNYYVQENSMVYFGAKGVTVVGATWTPDTARELHKLIKRVSRKPVLEVINTNYHTDRAGGNAYWKSIGAKVVSTRQTRDLMKSDWAEIVAFTRKGLPEYPDLPLVLPNVVHDGDFTLQEGKVRAFYAGPAHTPDGIFVYFPDEQVLYGNCILKEKLGNLSFADVKAYPQTLERLKAMKLPIKTVIGGHDSPLHGPELIDHYEALIKAAPQS
  
Inhibitor
Name:
BDBM50270748
Synonyms:
CHEMBL4125968
Type:
Small organic molecule
Emp. Form.:
C31H23N3O
Mol. Mass.:
453.5338
SMILES:
O=C(Nc1c(C#N)c(c(-c2ccccc2)n1Cc1ccccc1)-c1ccccc1)c1ccccc1
Structure:
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