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Target
Dual specificity mitogen-activated protein kinase kinase 1
Ligand
BDBM104963
Substrate
n/a
Meas. Tech.
ChEMBL_1709776 (CHEMBL4119825)
IC50
0.330000±n/a nM
Citation
Van Dort, ME; Galbán, S; Nino, CA; Hong, H; Apfelbaum, AA; Luker, GD; Thurber, GM; Atangcho, L; Besirli, CG; Ross, BD Structure-Guided Design and Initial Studies of a Bifunctional MEK/PI3K Inhibitor (ST-168). ACS Med Chem Lett 8:808-813 (2017) [PubMed] Article
More Info.:
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 1
Synonyms:
MP2K1_MOUSE | Map2k1 | Mek1 | Prkmk1
Type:
PROTEIN
Mol. Mass.:
43474.56
Organism:
Mus musculus
Description:
ChEMBL_506739
Residue:
393
Sequence:
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELLFGCHVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAASI