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Target
Calcium/calmodulin-dependent protein kinase kinase 2
Ligand
BDBM50271789
Substrate
n/a
Meas. Tech.
ChEBML_1711680
IC50
3981±n/a nM
Citation
 Price, DJ; Drewry, DH; Schaller, LT; Thompson, BD; Reid, PR; Maloney, PR; Liang, X; Banker, P; Buckholz, RG; Selley, PK; McDonald, OB; Smith, JL; Shearer, TW; Cox, RF; Williams, SP; Reid, RA; Tacconi, S; Faggioni, F; Piubelli, C; Sartori, I; Tessari, M; Wang, TY An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model. Bioorg Med Chem Lett 28:1958-1963 (2018) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase kinase 2
Synonyms:
2.7.11.17 | CaM-KK 2 | CaM-KK beta | CaM-kinase kinase 2 | CaM-kinase kinase beta | CaMKK 2 | CaMKK beta | Calcium/calmodulin-dependent protein kinase kinase 2 | Calcium/calmodulin-dependent protein kinase kinase beta | Camkk2 | KKCC2_MOUSE | Kiaa0787
Type:
PROTEIN
Mol. Mass.:
64610.75
Organism:
Mus musculus
Description:
ChEMBL_118133
Residue:
588
Sequence:
MSSCVSSQPTSDRVAPQDELGSGGGSREGQKPCEALRGLSSLSIHLGMESFIVVTECEPGRGVDLNLARDQPPEADGQELPLEASDPESRSPLSGRKMSLQEPSQGGPASSSNSLDMNGRCICPSLSYSPASSPQSSPRMPRRPTVESHHVSITGLQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGARPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTREWEPLSEPKEARQRRQPPGPRAGPCGGGGSALVKGGPCVESWGAPAPGSPPRMPPLQPEEVMEPE
  
Inhibitor
Name:
BDBM50271789
Synonyms:
CHEMBL4125686
Type:
Small organic molecule
Emp. Form.:
C19H18N2O2
Mol. Mass.:
306.3584
SMILES:
OC(=O)c1ccc(cc1C1CCCC1)-c1c[nH]c2ncccc12
Structure:
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