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Target
Calcium/calmodulin-dependent protein kinase kinase 2
Ligand
BDBM50271734
Substrate
n/a
Meas. Tech.
ChEBML_1711679
IC50
6.3±n/a nM
Citation
 Price, DJ; Drewry, DH; Schaller, LT; Thompson, BD; Reid, PR; Maloney, PR; Liang, X; Banker, P; Buckholz, RG; Selley, PK; McDonald, OB; Smith, JL; Shearer, TW; Cox, RF; Williams, SP; Reid, RA; Tacconi, S; Faggioni, F; Piubelli, C; Sartori, I; Tessari, M; Wang, TY An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model. Bioorg Med Chem Lett 28:1958-1963 (2018) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase kinase 2
Synonyms:
CAMKK2 | CAMKKB | Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKKB) | Calcium/calmodulin-dependent protein kinase kinase beta | KIAA0787 | KKCC2_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64746.61
Organism:
Homo sapiens (Human)
Description:
gi_27437015
Residue:
588
Sequence:
MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEPGCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQPPGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE
  
Inhibitor
Name:
BDBM50271734
Synonyms:
CHEMBL4128540
Type:
Small organic molecule
Emp. Form.:
C30H32N4O2
Mol. Mass.:
480.6007
SMILES:
CC(C)c1cc(ccc1C#N)-c1ccnc2[nH]c(cc12)-c1ccc(OCCN2CCOCC2)cc1C
Structure:
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