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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM42435
Substrate
n/a
Meas. Tech.
ChEMBL_1713838 (CHEMBL4123887)
IC50
3800±n/a nM
Citation
 Jaiteh, M; Zeifman, A; Saarinen, M; Svenningsson, P; Bréa, J; Loza, MI; Carlsson, J Docking Screens for Dual Inhibitors of Disparate Drug Targets for Parkinson's Disease. J Med Chem 61:5269-5278 (2018) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM42435
Synonyms:
(4-methylphenyl)methyl 5-amino-2-phenyltriazole-4-carboxylate | (4-methylphenyl)methyl 5-azanyl-2-phenyl-1,2,3-triazole-4-carboxylate | 4-methylbenzyl 5-amino-2-phenyl-2H-1,2,3-triazole-4-carboxylate | 5-amino-2-phenyl-4-triazolecarboxylic acid (4-methylphenyl)methyl ester | 5-amino-2-phenyl-triazole-4-carboxylic acid (4-methylbenzyl) ester | MLS000729082 | SMR000307360 | cid_1504749
Type:
Small organic molecule
Emp. Form.:
C17H16N4O2
Mol. Mass.:
308.3345
SMILES:
Cc1ccc(COC(=O)c2nn(nc2N)-c2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: