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Target
L-lactate dehydrogenase A chain
Ligand
BDBM50275213
Substrate
n/a
Meas. Tech.
ChEMBL_1714522 (CHEMBL4124571)
EC50
670±n/a nM
Citation
 Cao, W; Fang, L; Teng, S; Chen, H; Wang, Z Computer-aided discovery and biological characterization of human lactate dehydrogenase 5 inhibitors with anti-osteosarcoma activity. Bioorg Med Chem Lett 28:2229-2233 (2018) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase A chain
Synonyms:
Cell proliferation-inducing gene 19 protein | L-lactate dehydrogenase A | L-lactate dehydrogenase A Chain | LDH muscle subunit | LDH-A | LDH-M | LDHA | LDHA_HUMAN | Lactate dehydrogenase A (LDHA) | Renal carcinoma antigen NY-REN-59
Type:
Protein
Mol. Mass.:
36694.85
Organism:
Homo sapiens (Human)
Description:
P00338::PDB Code: 4ajp
Residue:
332
Sequence:
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF
  
Inhibitor
Name:
BDBM50275213
Synonyms:
CHEMBL4126939
Type:
Small organic molecule
Emp. Form.:
C29H33N3O4
Mol. Mass.:
487.59
SMILES:
Cc1cccc(OC[C@H](O)CN2CCN(CCN3C(=O)c4cccc5cccc(C3=O)c45)CC2)c1C |r|
Structure:
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