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Target
Intestinal-type alkaline phosphatase
Ligand
BDBM50275871
Substrate
n/a
Meas. Tech.
ChEMBL_1715065 (CHEMBL4125114)
IC50
344±n/a nM
Citation
 Sajid-Ur-Rehman, na; Saeed, A; Saddique, G; Ali Channar, P; Ali Larik, F; Abbas, Q; Hassan, M; Raza, H; Fattah, TA; Seo, SY Synthesis of sulfadiazinyl acyl/aryl thiourea derivatives as calf intestinal alkaline phosphatase inhibitors, pharmacokinetic properties, lead optimization, Lineweaver-Burk plot evaluation and binding analysis. Bioorg Med Chem 26:3707-3715 (2018) [PubMed]  Article 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Intestinal alkaline phosphatase | Intestinal alkaline phosphatase (IAP) | Intestinal-type alkaline phosphatase (IAP) | PPBI_BOVIN
Type:
Protein
Mol. Mass.:
57094.82
Organism:
Bos taurus (Cattle)
Description:
P19111
Residue:
533
Sequence:
MQGACVLLLLGLHLQLSLGLVPVEEEDPAFWNRQAAQALDVAKKLQPIQTAAKNVILFLGDGMGVPTVTATRILKGQMNGKLGPETPLAMDQFPYVALSKTYNVDRQVPDSAGTATAYLCGVKGNYRTIGVSAAARYNQCKTTRGNEVTSVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADLPADAQMNGCQDIAAQLVNNMDIDVILGGGRKYMFPVGTPDPEYPDDASVNGVRKRKQNLVQAWQAKHQGAQYVWNRTALLQAADDSSVTHLMGLFEPADMKYNVQQDHTKDPTLQEMTEVALRVVSRNPRGFYLFVEGGRIDHGHHDDKAYMALTEAGMFDNAIAKANELTSELDTLILVTADHSHVFSFGGYTLRGTSIFGLAPSKALDSKSYTSILYGNGPGYALGGGSRPDVNDSTSEDPSYQQQAAVPQASETHGGEDVAVFARGPQAHLVHGVEEETFVAHIMAFAGCVEPYTDCNLPAPTTATSIPDAAHLAASPPPLALLAGAMLLLLAPTLY
  
Inhibitor
Name:
BDBM50275871
Synonyms:
CHEMBL4128234
Type:
Small organic molecule
Emp. Form.:
C18H13Cl2N5O3S2
Mol. Mass.:
482.364
SMILES:
Clc1ccc(C(=O)NC(=S)Nc2ccc(cc2)S(=O)(=O)Nc2ncccn2)c(Cl)c1
Structure:
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