Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50276839
Substrate
n/a
Meas. Tech.
ChEBML_1716851
IC50
891±n/a nM
Citation
 Teleb, M; Kuppast, B; Spyridaki, K; Liapakis, G; Fahmy, H Synthesis of 2-imino and 2-hydrazono thiazolo[4,5-d]pyrimidines as corticotropin releasing factor (CRF) antagonists. Eur J Med Chem 138:900-908 (2017) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50276839
Synonyms:
CHEMBL4170184
Type:
Small organic molecule
Emp. Form.:
C19H25N5S
Mol. Mass.:
355.5
SMILES:
CCN(CC)c1nc(C)nc2n(-c3c(C)cc(C)cc3C)c(=N)sc12 |(16.61,-2.72,;16.61,-4.26,;17.95,-5.02,;19.28,-4.25,;19.28,-2.71,;17.95,-6.56,;16.63,-7.33,;16.62,-8.88,;15.29,-9.65,;17.96,-9.65,;19.3,-8.88,;20.78,-9.35,;20.77,-10.89,;19.42,-11.65,;18.1,-10.86,;19.41,-13.18,;20.74,-13.96,;20.73,-15.5,;22.08,-13.2,;22.09,-11.66,;23.42,-10.9,;21.68,-8.09,;23.22,-8.08,;20.76,-6.84,;19.29,-7.33,)|
Structure:
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