Reaction Details Report a problem with these data
Target
Solute carrier family 2, facilitated glucose transporter member 4
Ligand
BDBM50277375
Substrate
n/a
Meas. Tech.
ChEMBL_1717891 (CHEMBL4132891)
Ki
26000±n/a nM
Citation
 Wei, C; Bajpai, R; Sharma, H; Heitmeier, M; Jain, AD; Matulis, SM; Nooka, AK; Mishra, RK; Hruz, PW; Schiltz, GE; Shanmugam, M Development of GLUT4-selective antagonists for multiple myeloma therapy. Eur J Med Chem 139:573-586 (2017) [PubMed]  Article 
Target
Name:
Solute carrier family 2, facilitated glucose transporter member 4
Synonyms:
GLUT-4 | GLUT4_RAT | Glucose transporter type 4, insulin-responsive | Glut4 | Slc2a4 | Solute carrier family 2, facilitated glucose transporter member 4
Type:
PROTEIN
Mol. Mass.:
54896.34
Organism:
Rattus norvegicus
Description:
ChEMBL_108368
Residue:
509
Sequence:
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPGGPDSIPQGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPLLLAITVLPALLQLLLLPFCPESPRYLYIIRNLEGPARKSLKRLTGWADVSDALAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFELAGVEQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPSMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISATFRRTPSLLEQEVKPSTELEYLGPDEND
  
Inhibitor
Name:
BDBM50277375
Synonyms:
CHEMBL4173323
Type:
Small organic molecule
Emp. Form.:
C34H37N5O6
Mol. Mass.:
611.6875
SMILES:
CCOC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)OCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: