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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50452770
Substrate
n/a
Meas. Tech.
ChEBML_204589
Ki
26±n/a nM
Citation
 Holt, DA; Levy, MA; Oh, HJ; Erb, JM; Heaslip, JI; Brandt, M; Lan-Hargest, HY; Metcalf, BW Inhibition of steroid 5 alpha-reductase by unsaturated 3-carboxysteroids. J Med Chem 33:943-50 (1990) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50452770
Synonyms:
CHEMBL2311127
Type:
Small organic molecule
Emp. Form.:
C27H42FNO3
Mol. Mass.:
447.6257
SMILES:
[H][C@@]12CC[C@H](C(=O)N(C(C)C)C(C)C)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C(F)=C(CC[C@]12C)C(O)=O |c:29|
Structure:
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