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Target
Histone deacetylase 2
Ligand
BDBM50278208
Substrate
n/a
Meas. Tech.
ChEMBL_1718865 (CHEMBL4133865)
IC50
2800±n/a nM
Citation
 Hsieh, HY; Chuang, HC; Shen, FH; Detroja, K; Hsin, LW; Chen, CS Targeting breast cancer stem cells by novel HDAC3-selective inhibitors. Eur J Med Chem 140:42-51 (2017) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50278208
Synonyms:
CHEMBL4166987
Type:
Small organic molecule
Emp. Form.:
C22H20FN3O2
Mol. Mass.:
377.4115
SMILES:
C[C@@H](C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(F)cc1N)c1ccccc1 |r|
Structure:
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