Reaction Details Report a problem with these data
Target
Translocator protein
Ligand
BDBM22032
Substrate
n/a
Meas. Tech.
ChEMBL_1720335 (CHEMBL4135335)
Kd
11±n/a nM
Citation
 Kim, T; Son, WS; Morshed, MN; Londhe, AM; Jung, SY; Park, JH; Park, WK; Lim, SM; Park, KD; Cho, SJ; Jeong, KS; Lee, J; Pae, AN Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against A?-induced neurotoxicity. Eur J Med Chem 141:240-256 (2017) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN
Type:
Enzyme
Mol. Mass.:
18834.74
Organism:
Homo sapiens (Human)
Description:
P30536
Residue:
169
Sequence:
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
  
Inhibitor
Name:
BDBM22032
Synonyms:
1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide | CHEMBL15313 | N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide | PK 11195 | PK-11195 | PK11195 | RP 52028 | [3H]PK 11195
Type:
radiolabeled ligand
Emp. Form.:
C21H21ClN2O
Mol. Mass.:
352.857
SMILES:
CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl
Structure:
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