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Target
Dopamine beta-hydroxylase
Ligand
BDBM50015625
Substrate
n/a
Meas. Tech.
ChEBML_59420
IC50
5300±n/a nM
Citation
 McCarthy, JR; Matthews, DP; Broersma, RJ; McDermott, RD; Kastner, PR; Hornsperger, JM; Demeter, DA; Weintraub, HJ; Whitten, JP 1-(Thienylalkyl)imidazole-2(3H)-thiones as potent competitive inhibitors of dopamine beta-hydroxylase. J Med Chem 33:1866-73 (1990) [PubMed]  Article 
Target
Name:
Dopamine beta-hydroxylase
Synonyms:
DBH | DOPO_BOVIN
Type:
PROTEIN
Mol. Mass.:
68136.39
Organism:
Bos taurus
Description:
ChEMBL_50738
Residue:
610
Sequence:
MQVPSPSVREAASMYGTAVAVFLVILVAALQGSAPAESPFPFHIPLDPEGTLELSWNISYAQETIYFQLLVRELKAGVLFGMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDSQQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESINTSGLHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIVMYEPIVTEGNEALVHHMEVFQCAAEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAKAFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMELGLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARDGRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEMCVNYVHYYPQTQLELCKSAVDPGFLHKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSFNREVLKALYGFAPISMHCNRSSAVRFQGEWNRQPLPEIVSRLEEPTPHCPASQAQSPAGPTVLNISGGKG
  
Inhibitor
Name:
BDBM50015625
Synonyms:
1-Thiophen-3-ylmethyl-1,3-dihydro-imidazole-2-thione | CHEMBL55206
Type:
Small organic molecule
Emp. Form.:
C8H8N2S2
Mol. Mass.:
196.293
SMILES:
S=c1[nH]ccn1Cc1ccsc1
Structure:
Search PDB for entries with ligand similarity: