Reaction Details Report a problem with these data
Target
E3 SUMO-protein ligase CBX4
Ligand
BDBM50194259
Substrate
n/a
Meas. Tech.
ChEMBL_1723553 (CHEMBL4138831)
Kd
97±n/a nM
Citation
 Teske, KA; Hadden, MK Methyllysine binding domains: Structural insight and small molecule probe development. Eur J Med Chem 136:14-35 (2017) [PubMed]  Article 
Target
Name:
E3 SUMO-protein ligase CBX4
Synonyms:
6.3.2.- | CBX4 | CBX4_HUMAN | Chromobox protein homolog 4 | Pc2 | Polycomb 2 homolog | hPc2
Type:
PROTEIN
Mol. Mass.:
61401.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108273
Residue:
560
Sequence:
MELPAVGEHVFAVESIEKKRIRKGRVEYLVKWRGWSPKYNTWEPEENILDPRLLIAFQNRERQEQLMGYRKRGPKPKPLVVQVPTFARRSNVLTGLQDSSTDNRAKLDLGAQGKGQGHQYELNSKKHHQYQPHSKERAGKPPPPGKSGKYYYQLNSKKHHPYQPDPKMYDLQYQGGHKEAPSPTCPDLGAKSHPPDKWAQGAGAKGYLGAVKPLAGAAGAPGKGSEKGPPNGMMPAPKEAVTGNGIGGKMKIVKNKNKNGRIVIVMSKYMENGMQAVKIKSGEVAEGEARSPSHKKRAADERHPPADRTFKKAAGAEEKKVEAPPKRREEEVSGVSDPQPQDAGSRKLSPTKEAFGEQPLQLTTKPDLLAWDPARNTHPPSHHPHPHPHHHHHHHHHHHHAVGLNLSHVRKRCLSETHGEREPCKKRLTARSISTPTCLGGSPAAERPADLPPAAALPQPEVILLDSDLDEPIDLRCVKTRSEAGEPPSSLQVKPETPASAAVAVAAAAAPTTTAEKPPAEAQDEPAESLSEFKPFFGNIIITDVTANCLTVTFKEYVTV
  
Inhibitor
Name:
BDBM50194259
Synonyms:
CHEMBL3939958
Type:
Small organic molecule
Emp. Form.:
C43H66N6O8
Mol. Mass.:
795.0195
SMILES:
CCN(CC)CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(cc1)C(C)(C)C)C(=O)N[C@@H](CO)C(=O)OC |r|
Structure:
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