Reaction Details Report a problem with these data
Target
Eukaryotic initiation factor 4A-I
Ligand
BDBM50283445
Substrate
n/a
Meas. Tech.
ChEMBL_1725517 (CHEMBL4140795)
IC50
>100000±n/a nM
Citation
 Mizojiri, R; Nakata, D; Satoh, Y; Morishita, D; Shibata, S; Iwatani-Yoshihara, M; Kosugi, Y; Kosaka, M; Takeda, J; Sasaki, S; Takami, K; Fukuda, K; Kamaura, M; Sasaki, S; Arai, R; Cary, DR; Imaeda, Y Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1 ACS Med Chem Lett 8:1077-1082 (2017) [PubMed]  Article 
Target
Name:
Eukaryotic initiation factor 4A-I
Synonyms:
ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I
Type:
PROTEIN
Mol. Mass.:
46146.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_864983
Residue:
406
Sequence:
MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
  
Inhibitor
Name:
BDBM50283445
Synonyms:
CHEMBL4175313
Type:
Small organic molecule
Emp. Form.:
C35H25BrClF3N4O3
Mol. Mass.:
721.95
SMILES:
FC(F)(F)c1cccc(c1)-c1cc(cn(-c2ccccc2)c1=O)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cn1 |r|
Structure:
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