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Target
Alpha-1A adrenergic receptor
Ligand
BDBM50284026
Substrate
n/a
Meas. Tech.
ChEMBL_1726507 (CHEMBL4141785)
IC50
4.3±n/a nM
Citation
 Petty, A; Idippily, N; Bobba, V; Geldenhuys, WJ; Zhong, B; Su, B; Wang, B Design and synthesis of small molecule agonists of EphA2 receptor. Eur J Med Chem 143:1261-1276 (2018) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_RAT | Adra1a | Adra1c | Alpha-1 adrenoreceptor | Alpha-1A adrenoceptor | Alpha-1A adrenoreceptor | Alpha-1C adrenergic receptor | adrenergic Alpha1A
Type:
Protein
Mol. Mass.:
51620.15
Organism:
Rattus norvegicus (Rat)
Description:
P43140
Residue:
466
Sequence:
MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
  
Inhibitor
Name:
BDBM50284026
Synonyms:
CHEMBL4166644
Type:
Small organic molecule
Emp. Form.:
C29H31N5O4
Mol. Mass.:
513.5875
SMILES:
COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)Cc1ccc(OCc2ccccc2)cc1
Structure:
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