Reaction Details Report a problem with these data
Target
Eukaryotic elongation factor 2 kinase
Ligand
BDBM50284575
Substrate
n/a
Meas. Tech.
ChEMBL_1727899 (CHEMBL4143177)
IC50
360±n/a nM
Citation
 Guo, Y; Zhao, Y; Wang, G; Chen, Y; Jiang, Y; Ouyang, L; Liu, B Design, synthesis and structure-activity relationship of a focused library of ?-phenylalanine derivatives as novel eEF2K inhibitors with apoptosis-inducing mechanisms in breast cancer. Eur J Med Chem 143:402-418 (2018) [PubMed]  Article 
Target
Name:
Eukaryotic elongation factor 2 kinase
Synonyms:
2.7.11.20 | Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EF2K_RAT | Eef2k | Eukaryotic elongation factor 2 kinase | eEF-2 kinase | eEF-2K
Type:
PROTEIN
Mol. Mass.:
81459.15
Organism:
Rattus norvegicus
Description:
ChEMBL_109466
Residue:
724
Sequence:
MADEDLIFRLEGVDGGGSSGAGRHGDSDTDSDDDEGYFICPITDDHMSNQNVNSKGQGYYNNLLKTECGSTGSPASSFHFKEAWKHAIEKAKHMPDPWAEFHLEDIATEHATRHRYNAVTGEWLKDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQHWKGASNYVAKRYLEPVDRSVYFEDVQLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRQGQPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTEKGTDFGDGNLGVRGMALFFYSHACNRICQSMGLAPFDLSPREQDAVNQSTKLLQSAKTILRGTEEKCGSPRIRTLSGSRPPLLLRLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFGDLDNMGPRDHDRMDNHRDSENSGDSGYPSEKRSDLDDPEPREHGHSNGNRRPESDEDSLGSSGRVCVETWNLLNPSRLHLPRPSAVALEVQRLNALDLGRKIGKSVLGKVHLAMVRYHEGGRFCEKDEEWDQESAIFHLEHAADLGELEAIVGLGLMYSQLPHHILADVSLEETEENKTKGFDYLLKAAEAGDRQSMILVARAFDTGLNLSPDRCQDWSEALHWYNTALETTDCDEGGEYDGIQDEPQYALLAREAEMLLTGGFGLDKNPQRSGDLYTQAAEAAMEAMKGRLANQYYEKAEEAWAQMEE
  
Inhibitor
Name:
BDBM50284575
Synonyms:
CHEMBL4173539
Type:
Small organic molecule
Emp. Form.:
C16H23NOSe
Mol. Mass.:
324.32
SMILES:
[#6]-[#6]C1([#8])[#6]-[#6]([Se;v2][#6](=[#7]1)-c1ccc(-[#6])cc1)-[#6](-[#6])-[#6] |c:7|
Structure:
Search PDB for entries with ligand similarity: