Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50040961
Substrate
n/a
Meas. Tech.
ChEMBL_1728850 (CHEMBL4144128)
EC50
64±n/a nM
Citation
 Han, S; Thoresen, L; Jung, JK; Zhu, X; Thatte, J; Solomon, M; Gaidarov, I; Unett, DJ; Yoon, WH; Barden, J; Sadeque, A; Usmani, A; Chen, C; Semple, G; Grottick, AJ; Al-Shamma, H; Christopher, R; Jones, RM Discovery of APD371: Identification of a Highly Potent and Selective CB ACS Med Chem Lett 8:1309-1313 (2017) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50040961
Synonyms:
CHEMBL3354952
Type:
Small organic molecule
Emp. Form.:
C18H19F2N3O2
Mol. Mass.:
347.3592
SMILES:
[H][C@]12C[C@@]1([H])c1c(C2)c(nn1-c1ccc(F)cc1F)C(=O)NC(C)(C)CO |r|
Structure:
Search PDB for entries with ligand similarity: