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Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM50290909
Substrate
n/a
Meas. Tech.
ChEMBL_1730826 (CHEMBL4146362)
IC50
670±n/a nM
Citation
 Du, Y; Zhang, Y; Ling, H; Li, Q; Shen, J Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site. Eur J Med Chem 144:692-700 (2018) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM50290909
Synonyms:
CHEMBL4164960
Type:
Small organic molecule
Emp. Form.:
C23H31N3O8S
Mol. Mass.:
509.573
SMILES:
CCOc1cc(NS(C)(=O)=O)c(OCC)cc1CNC(=O)Nc1ccc(OCC)c(c1)C(=O)OC
Structure:
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