Reaction Details Report a problem with these data
Target
rRNA adenine N-6-methyltransferase
Ligand
BDBM50291837
Substrate
n/a
Meas. Tech.
ChEMBL_1731828 (CHEMBL4147364)
Ki
147600±n/a nM
Citation
 Foik, IP; Tuszynska, I; Feder, M; Purta, E; Stefaniak, F; Bujnicki, JM Novel inhibitors of the rRNA ErmC' methyltransferase to block resistance to macrolides, lincosamides, streptogramine B antibiotics. Eur J Med Chem 146:60-67 (2018) [PubMed]  Article 
Target
Name:
rRNA adenine N-6-methyltransferase
Synonyms:
2.1.1.184 | ERMA_STAAN | Erythromycin resistance protein | Macrolide-lincosamide-streptogramin B resistance protein | ermA1 | ermA2 | ermA3 | ermA4 | ermA5 | rRNA adenine N-6-methyltransferase
Type:
PROTEIN
Mol. Mass.:
28433.06
Organism:
Staphylococcus aureus (strain N315)
Description:
ChEMBL_117813
Residue:
243
Sequence:
MNQKNPKDTQNFITSKKHVKEILNHTNISKQDNVIEIGSGKGHFTKELVKMSRSVTAIEIDGGLCQVTKEAVNPSENIKVIQTDILKFSFPKHINYKIYGNIPYNISTDIVKRITFESQAKYSYLIVEKGFAKRLQNLQRALGLLLMVEMDIKMLKKVPPLYFHPKPSVDSVLIVLERHQPLISKKDYKKYRSFVYKWVNREYRVLFTKNQFRQALKHANVTNINKLSKEQFLSIFNSYKLFH
  
Inhibitor
Name:
BDBM50291837
Synonyms:
CHEMBL4172068
Type:
Small organic molecule
Emp. Form.:
C14H14F3N5O2
Mol. Mass.:
341.2885
SMILES:
FC(F)(F)c1ccc(nc1)N1CCN(CC1)C(=O)c1c[nH]c(=O)[nH]1
Structure:
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