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Target
Tumor necrosis factor ligand superfamily member 11
Ligand
BDBM50291909
Substrate
n/a
Meas. Tech.
ChEMBL_1731581 (CHEMBL4147117)
Kd
4540±n/a nM
Citation
 Liu, C; Chen, X; Zhi, X; Weng, W; Li, Q; Li, X; Zou, Y; Su, J; Hu, HG Structure-based development of an osteoprotegerin-like glycopeptide that blocks RANKL/RANK interactions and reduces ovariectomy-induced bone loss in mice. Eur J Med Chem 145:661-672 (2018) [PubMed]  Article 
Target
Name:
Tumor necrosis factor ligand superfamily member 11
Synonyms:
CD_antigen=CD254 | ODF | OPGL | RANKL | TNF11_HUMAN | TNFSF11 | TRANCE
Type:
PROTEIN
Mol. Mass.:
35484.75
Organism:
Homo sapiens
Description:
ChEMBL_106141
Residue:
317
Sequence:
MRRASRDYTKYLRGSEEMGGGPGAPHEGPLHAPPPPAPHQPPAASRSMFVALLGLGLGQVVCSVALFFYFRAQMDPNRISEDGTHCIYRILRLHENADFQDTTLESQDTKLIPDSCRRIKQAFQGAVQKELQHIVGSQHIRAEKAMVDGSWLDLAKRSKLEAQPFAHLTINATDIPSGSHKVSLSSWYHDRGWAKISNMTFSNGKLIVNQDGFYYLYANICFRHHETSGDLATEYLQLMVYVTKTSIKIPSSHTLMKGGSTKYWSGNSEFHFYSINVGGFFKLRSGEEISIEVSNPSLLDPDQDATYFGAFKVRDID
  
Inhibitor
Name:
BDBM50291909
Synonyms:
CHEMBL4161101
Type:
Small organic molecule
Emp. Form.:
C85H131N21O28S2
Mol. Mass.:
1959.204
SMILES:
CC[C@H](C)[C@@H]1NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@H](CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)NC(C)=O |r|
Structure:
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