Reaction Details Report a problem with these data
Target
Sodium-dependent phosphate transport protein 2A
Ligand
BDBM50327356
Substrate
n/a
Meas. Tech.
ChEMBL_1734215 (CHEMBL4149751)
IC50
6500±n/a nM
Citation
 Filipski, KJ; Sammons, MF; Bhattacharya, SK; Panteleev, J; Brown, JA; Loria, PM; Boehm, M; Smith, AC; Shavnya, A; Conn, EL; Song, K; Weng, Y; Facemire, C; Jüppner, H; Clerin, V Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett 9:440-445 (2018) [PubMed]  Article 
Target
Name:
Sodium-dependent phosphate transport protein 2A
Synonyms:
NPT2 | NPT2A_HUMAN | Na(+)-dependent phosphate cotransporter 2A | Na(+)/Pi cotransporter 2A | NaPi-2a | NaPi-3 | SLC17A2 | SLC34A1 | Sodium-dependent phosphate transport protein 2A | Sodium-phosphate transport protein 2A | Sodium/phosphate cotransporter 2A | Solute carrier family 34 member 1
Type:
PROTEIN
Mol. Mass.:
68955.19
Organism:
Homo sapiens
Description:
ChEMBL_116742
Residue:
639
Sequence:
MLSYGERLGSPAVSPLPVRGGHVMRGTAFAYVPSPQVLHRIPGTSAYAFPSLGPVALAEHTCPCGEVLERHEPLPAKLALEEEQKPESRLVPKLRQAGAMLLKVPLMLTFLYLFVCSLDMLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHITRLVVASFNIHGGRDAPDLLKIITEPFTKLIIQLDESVITSIATGDESLRNHSLIQIWCHPDSLQAPTSMSRAEANSSQTLGNATMEKCNHIFVDTGLPDLAVGLILLAGSLVLLCTCLILLVKMLNSLLKGQVAKVIQKVINTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSAFQIALCHFFFNISGILLWYPVPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQVMVGVGTPFGALLAFVVLINVLQSRSPGHLPKWLQTWDFLPRWMHSLKPLDHLITRATLCCARPEPRSPPLPPRVFLEELPPATPSPRLALPAHHNATRL
  
Inhibitor
Name:
BDBM50327356
Synonyms:
CHEMBL4172584
Type:
Small organic molecule
Emp. Form.:
C20H19F3N6
Mol. Mass.:
400.4003
SMILES:
Cc1cc2nc(c(C#N)c(N3CCC(CC3)Nc3ccccn3)c2[nH]1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: