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Target
Sodium-dependent phosphate transport protein 2A
Ligand
BDBM50341383
Substrate
n/a
Meas. Tech.
ChEMBL_1734230 (CHEMBL4149766)
IC50
540±n/a nM
Citation
 Filipski, KJ; Sammons, MF; Bhattacharya, SK; Panteleev, J; Brown, JA; Loria, PM; Boehm, M; Smith, AC; Shavnya, A; Conn, EL; Song, K; Weng, Y; Facemire, C; Jüppner, H; Clerin, V Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett 9:440-445 (2018) [PubMed]  Article 
Target
Name:
Sodium-dependent phosphate transport protein 2A
Synonyms:
NPT2A_MOUSE | Na(+)-dependent phosphate cotransporter 2A | Na(+)/Pi cotransporter 2A | NaPi-2a | NaPi-7 | Npt2 | Slc17a2 | Slc34a1 | Sodium-dependent phosphate transport protein 2A | Sodium-phosphate transport protein 2A | Sodium/phosphate cotransporter 2A | Solute carrier family 34 member 1
Type:
PROTEIN
Mol. Mass.:
68791.17
Organism:
Mus musculus
Description:
ChEMBL_118100
Residue:
637
Sequence:
MMSYSERLGGPAVSPLPVRGRHMVHGATFAYVPSPQVLHRIPGTSTYAISSLSPVTLTEHSCPCGEVLECHDPLPTKLAQEEEQKPEPRLSQKLAQVGTKLLKVPLMLAFLYLFVCSLDVLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHVTGLVVASFNIRGGRDAPDLLKVITEPFTRLIIQLDKSVITSIAVGDESLRNHSLIRIWCHPDTTEASTSMSRVEAIGSLANTTMEKCNHIFVDTGLPDLAVGLILLAGSLVVLCTCLILLVKMLNSLLKGQVMSSRRSSTQTDFPAPFTWVTGYFAMVVGASMTFVVQSSSVFTSAITPLIGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSSFQIALCHFFFNISGILLWYPLPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWQAMVGVGTPFGALLAFVVLVNVLQSRSPGHLPKWLQTWDFLPRWMHSLQPLDGLITRATLCYARPEPRSPQLPPRVFLEELPPATPSPRLALPAHHNATRL
  
Inhibitor
Name:
BDBM50341383
Synonyms:
CHEMBL4175607
Type:
Small organic molecule
Emp. Form.:
C15H14ClF3N4O2
Mol. Mass.:
374.745
SMILES:
Cc1[nH]c2c(N3CCO[C@H](CO)C3)c(C#N)c(nc2c1Cl)C(F)(F)F |r|
Structure:
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