Reaction Details Report a problem with these data
Target
Sodium-dependent phosphate transport protein 2C
Ligand
BDBM50327361
Substrate
n/a
Meas. Tech.
ChEMBL_1734217 (CHEMBL4149753)
IC50
>25000±n/a nM
Citation
 Filipski, KJ; Sammons, MF; Bhattacharya, SK; Panteleev, J; Brown, JA; Loria, PM; Boehm, M; Smith, AC; Shavnya, A; Conn, EL; Song, K; Weng, Y; Facemire, C; Jüppner, H; Clerin, V Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett 9:440-445 (2018) [PubMed]  Article 
Target
Name:
Sodium-dependent phosphate transport protein 2C
Synonyms:
NPT2C | NPT2C_HUMAN | NPTIIC | Na(+)-dependent phosphate cotransporter 2C | Na(+)/Pi cotransporter 2C | NaPi-2c | SLC34A3 | Sodium-dependent phosphate transport protein 2C | Sodium-phosphate transport protein 2C | Sodium/inorganic phosphate cotransporter IIC | Sodium/phosphate cotransporter 2C | Solute carrier family 34 member 3
Type:
PROTEIN
Mol. Mass.:
63559.05
Organism:
Homo sapiens
Description:
ChEMBL_118145
Residue:
599
Sequence:
MPSSLPGSQVPHPTLDAVDLVEKTLRNEGTSSSAPVLEEGDTDPWTLPQLKDTSQPWKELRVAGRLRRVAGSVLKACGLLGSLYFFICSLDVLSSAFQLLGSKVAGDIFKDNVVLSNPVAGLVIGVLVTALVQSSSTSSSIVVSMVAAKLLTVRVSVPIIMGVNVGTSITSTLVSMAQSGDRDEFQRAFSGSAVHGIFNWLTVLVLLPLESATALLERLSELALGAASLTPRAQAPDILKVLTKPLTHLIVQLDSDMIMSSATGNATNSSLIKHWCGTTGQPTQENSSCGAFGPCTEKNSTAPADRLPCRHLFAGTELTDLAVGCILLAGSLLVLCGCLVLIVKLLNSVLRGRVAQVVRTVINADFPFPLGWLGGYLAVLAGAGLTFALQSSSVFTAAVVPLMGVGVISLDRAYPLLLGSNIGTTTTALLAALASPADRMLSALQVALIHFFFNLAGILLWYLVPALRLPIPLARHFGVVTARYRWVAGVYLLLGFLLLPLAAFGLSLAGGMELAAVGGPLVGLVLLVILVTVLQRRRPAWLPVRLRSWAWLPVWLHSLEPWDRLVTRCCPCNVCSPPKATTKEAYCYENPEILASQQL
  
Inhibitor
Name:
BDBM50327361
Synonyms:
CHEMBL4172179
Type:
Small organic molecule
Emp. Form.:
C17H16F3N5O
Mol. Mass.:
363.337
SMILES:
FC(F)(F)c1nc2cc[nH]c2c(N2CCC3(CCNC3=O)CC2)c1C#N
Structure:
Search PDB for entries with ligand similarity: