Reaction Details Report a problem with these data
Target
Sodium-dependent phosphate transporter 1
Ligand
BDBM50327356
Substrate
n/a
Meas. Tech.
ChEMBL_1734218 (CHEMBL4149754)
IC50
>14000±n/a nM
Citation
 Filipski, KJ; Sammons, MF; Bhattacharya, SK; Panteleev, J; Brown, JA; Loria, PM; Boehm, M; Smith, AC; Shavnya, A; Conn, EL; Song, K; Weng, Y; Facemire, C; Jüppner, H; Clerin, V Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett 9:440-445 (2018) [PubMed]  Article 
Target
Name:
Sodium-dependent phosphate transporter 1
Synonyms:
GLVR-1 | GLVR1 | Gibbon ape leukemia virus receptor 1 | Leukemia virus receptor 1 homolog | PIT1 | Phosphate transporter 1 | PiT-1 | S20A1_HUMAN | SLC20A1 | Sodium-dependent phosphate transporter 1 | Solute carrier family 20 member 1
Type:
PROTEIN
Mol. Mass.:
73702.88
Organism:
Homo sapiens
Description:
ChEMBL_118154
Residue:
679
Sequence:
MATLITSTTAATAASGPLVDYLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILASIFETVGSVLLGAKVSETIRKGLIDVEMYNSTQGLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILHKADPVPNGLRALPVFYACTVGINLFSIMYTGAPLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREIKCSPSESPLMEKKNSLKEDHEETKLSVGDIENKHPVSEVGPATVPLQAVVEERTVSFKLGDLEEAPERERLPSVDLKEETSIDSTVNGAVQLPNGNLVQFSQAVSNQINSSGHYQYHTVHKDSGLYKELLHKLHLAKVGDCMGDSGDKPLRRNNSYTSYTMAICGMPLDSFRAKEGEQKGEEMEKLTWPNADSKKRIRMDSYTSYCNAVSDLHSASEIDMSVKAEMGLGDRKGSNGSLEEWYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYDTGDVSSKVATPIWLLLYGGVGICVGLWVWGRRVIQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAIFRYVILRM
  
Inhibitor
Name:
BDBM50327356
Synonyms:
CHEMBL4172584
Type:
Small organic molecule
Emp. Form.:
C20H19F3N6
Mol. Mass.:
400.4003
SMILES:
Cc1cc2nc(c(C#N)c(N3CCC(CC3)Nc3ccccn3)c2[nH]1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: