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Target
Signal transducer and activator of transcription 3
Ligand
BDBM50366597
Substrate
n/a
Meas. Tech.
ChEMBL_1735419 (CHEMBL4150955)
EC50
1900±n/a nM
Citation
 Löcken, H; Clamor, C; Müller, K Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells. J Nat Prod 81:1636-1644 (2018) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) | STAT3_HUMAN | STAT3 | APRF
Type:
Protein
Mol. Mass.:
88064.31
Organism:
Human
Description:
P40763
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
  
Inhibitor
Name:
BDBM50366597
Synonyms:
2-Acetylfuranonaphthoquinone | BBI-608 | Napabucasin
Type:
Small organic molecule
Emp. Form.:
C14H8O4
Mol. Mass.:
240.21
SMILES:
CC(=O)c1cc2c(o1)C(=O)c3ccccc3C2=O
Structure:
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