Reaction Details Report a problem with these data
Target
Stromal cell-derived factor 1
Ligand
BDBM50042992
Substrate
n/a
Meas. Tech.
ChEMBL_1736458 (CHEMBL4151994)
Ki
1780±n/a nM
Citation
 Regenass, P; Abboud, D; Daubeuf, F; Lehalle, C; Gizzi, P; Riché, S; Hachet-Haas, M; Rohmer, F; Gasparik, V; Boeglin, D; Haiech, J; Knehans, T; Rognan, D; Heissler, D; Marsol, C; Villa, P; Galzi, JL; Hibert, M; Frossard, N; Bonnet, D Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia. J Med Chem 61:7671-7686 (2018) [PubMed]  Article 
Target
Name:
Stromal cell-derived factor 1
Synonyms:
CXCL12 | Chemokine CXCL12 | SDF1 | SDF1A | SDF1B | SDF1_HUMAN
Type:
Enzyme
Mol. Mass.:
10677.83
Organism:
Homo sapiens (Human)
Description:
P48061
Residue:
93
Sequence:
MNAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM
  
Inhibitor
Name:
BDBM50042992
Synonyms:
3-(4-Hydroxy-3-methoxy-phenyl)-1-(4-methoxy-phenyl)-propenone | CHEMBL130639
Type:
Small organic molecule
Emp. Form.:
C17H16O4
Mol. Mass.:
284.3065
SMILES:
COc1ccc(cc1)C(=O)\C=C\c1ccc(O)c(OC)c1
Structure:
Search PDB for entries with ligand similarity: