Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1E
Ligand
BDBM50370517
Substrate
n/a
Meas. Tech.
ChEMBL_1737627 (CHEMBL4153377)
Ki
403±n/a nM
Citation
 Linkens, K; Schmidt, HR; Sahn, JJ; Kruse, AC; Martin, SF Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties. Eur J Med Chem 151:557-567 (2018) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1E
Synonyms:
5-HT-1E | 5-HT1E | 5-Hydroxytryptamine Receptor Subtype 1E (5HT1E) | 5-hydroxytryptamine receptor 1E | 5-hydroxytryptamine receptor 1E (5-HT-1E) (S31) | 5-hydroxytryptamine receptor 1E (5-HT-1E) (Serotonin receptor 1E) (5-HT1E) (S31). | 5HT1E_HUMAN | HTR1E | S31 | Serotonin (5-HT) receptor | Serotonin 1e (5-HT1e) receptor | Serotonin Receptor 1E
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41697.80
Organism:
Homo sapiens (Human)
Description:
gi_112822
Residue:
365
Sequence:
MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREHT
  
Inhibitor
Name:
BDBM50370517
Synonyms:
CHEMBL4163428 | US10954217, Example 00227
Type:
Small organic molecule
Emp. Form.:
C21H25N3O2
Mol. Mass.:
351.4421
SMILES:
CN1CCN(CC1)c1ccc2CN(Cc2c1)C(=O)OCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: