Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50370628
Substrate
n/a
Meas. Tech.
ChEMBL_1737621 (CHEMBL4153371)
Ki
13±n/a nM
Citation
 Linkens, K; Schmidt, HR; Sahn, JJ; Kruse, AC; Martin, SF Investigating isoindoline, tetrahydroisoquinoline, and tetrahydrobenzazepine scaffolds for their sigma receptor binding properties. Eur J Med Chem 151:557-567 (2018) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM50370628
Synonyms:
CHEMBL4166276 | US10954217, Example 00262
Type:
Small organic molecule
Emp. Form.:
C27H35N3O2
Mol. Mass.:
433.5857
SMILES:
O=C(OCc1ccccc1)N1CCCc2ccc(cc2C1)N1CCN(CC1)C1CCCC1
Structure:
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