Reaction Details Report a problem with these data
Target
Focal adhesion kinase 1
Ligand
BDBM50449753
Substrate
n/a
Meas. Tech.
ChEMBL_1740584 (CHEMBL4156334)
IC50
117500±n/a nM
Citation
 Alt?ntop, MD; Sever, B; Akal?n Çiftçi, G; Turan-Zitouni, G; Kaplanc?kl?, ZA; Özdemir, A Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors. Eur J Med Chem 155:905-924 (2018) [PubMed]  Article 
Target
Name:
Focal adhesion kinase 1
Synonyms:
2.7.10.2 | FADK 1 | FAK1_RAT | FRNK | Fak | Fak1 | Focal adhesion kinase 1 | Focal adhesion kinase-related nonkinase | Protein-tyrosine kinase 2 | Ptk2 | p125FAK | pp125FAK
Type:
PROTEIN
Mol. Mass.:
119717.70
Organism:
Rattus norvegicus
Description:
ChEMBL_101321
Residue:
1055
Sequence:
MAAAYLDPNLNHTPSSSTKTHLGTGTERSPGAMERVLKVFHYFESSNEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQDIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPQKEGERALPSIPKLANNEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGVYLSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKVQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQISGYPGSHGIPAMAGSIYPGQASLLDQTELWNHRPQEMSMWQPSVEDSAALDLRGMGQVLPPHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSFQGPTGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLSNLSSISSPAESYNEGVKPWRLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPILPASTHREIEMAQKLLNSDLGELISKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
  
Inhibitor
Name:
BDBM50449753
Synonyms:
CHEMBL4170467
Type:
Small organic molecule
Emp. Form.:
C22H19FN4O3S2
Mol. Mass.:
470.54
SMILES:
Fc1ccc2nc(NC(=O)CSc3nnc(COc4ccc5CCCCc5c4)o3)sc2c1
Structure:
Search PDB for entries with ligand similarity: