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Target
RAC-alpha serine/threonine-protein kinase
Ligand
BDBM50449753
Substrate
n/a
Meas. Tech.
ChEMBL_1740582 (CHEMBL4156332)
IC50
165000±n/a nM
Citation
 Alt?ntop, MD; Sever, B; Akal?n Çiftçi, G; Turan-Zitouni, G; Kaplanc?kl?, ZA; Özdemir, A Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors. Eur J Med Chem 155:905-924 (2018) [PubMed]  Article 
Target
Name:
RAC-alpha serine/threonine-protein kinase
Synonyms:
2.7.11.1 | AKT1_RAT | Akt1 | PKB | PKB alpha | Protein kinase B | Protein kinase B alpha | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase
Type:
PROTEIN
Mol. Mass.:
55728.72
Organism:
Rattus norvegicus
Description:
ChEMBL_102911
Residue:
480
Sequence:
MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVALAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
  
Inhibitor
Name:
BDBM50449753
Synonyms:
CHEMBL4170467
Type:
Small organic molecule
Emp. Form.:
C22H19FN4O3S2
Mol. Mass.:
470.54
SMILES:
Fc1ccc2nc(NC(=O)CSc3nnc(COc4ccc5CCCCc5c4)o3)sc2c1
Structure:
Search PDB for entries with ligand similarity: