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Target
Carbonic anhydrase 2
Ligand
BDBM50449812
Substrate
n/a
Meas. Tech.
ChEMBL_1740759 (CHEMBL4156509)
Kd
0.370000±n/a nM
Citation
 Zak?auskas, A; ?apkauskait?, E; Jezep?ikas, L; Linkuvien?, V; Ki?onait?, M; Smirnov, A; Manakova, E; Gra?ulis, S; Matulis, D Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases. Eur J Med Chem 156:61-78 (2018) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50449812
Synonyms:
CHEMBL4176828
Type:
Small organic molecule
Emp. Form.:
C15H22ClN3O4S
Mol. Mass.:
375.871
SMILES:
NS(=O)(=O)c1cc(C(=O)NCCO)c(NC2CCCCC2)cc1Cl
Structure:
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