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Target
Thiosulfate sulfurtransferase
Ligand
BDBM50450006
Substrate
n/a
Meas. Tech.
ChEMBL_1741629 (CHEMBL4157379)
IC50
>100000±n/a nM
Citation
 Abdeen, S; Kunkle, T; Salim, N; Ray, AM; Mammadova, N; Summers, C; Stevens, M; Ambrose, AJ; Park, Y; Schultz, PG; Horwich, AL; Hoang, QQ; Chapman, E; Johnson, SM Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA). J Med Chem 61:7345-7357 (2018) [PubMed]  Article 
Target
Name:
Thiosulfate sulfurtransferase
Synonyms:
2.8.1.1 | Rhodanese | THTR_HUMAN | TST | Thiosulfate sulfurtransferase
Type:
PROTEIN
Mol. Mass.:
33432.06
Organism:
Homo sapiens
Description:
ChEMBL_118080
Residue:
297
Sequence:
MVHQVLYRALVSTKWLAESIRTGKLGPGLRVLDASWYSPGTREARKEYLERHVPGASFFDIEECRDTASPYEMMLPSEAGFAEYVGRLGISNHTHVVVYDGEHLGSFYAPRVWWMFRVFGHRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLDRSLLKTYEQVLENLESKRFQLVDSRSQGRFLGTEPEPDAVGLDSGHIRGAVNMPFMDFLTEDGFEKGPEELRALFQTKKVDLSQPLIATCRKGVTACHVALAAYLCGKPDVAVYDGSWSEWFRRAPPESRVSQGKSEKA
  
Inhibitor
Name:
BDBM50450006
Synonyms:
CHEMBL3970551
Type:
Small organic molecule
Emp. Form.:
C27H17F6N3O5S2
Mol. Mass.:
641.561
SMILES:
FC(F)(F)c1cccc(c1)S(=O)(=O)Nc1ccc(cc1)-c1nc2cc(NS(=O)(=O)c3cccc(c3)C(F)(F)F)ccc2o1
Structure:
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