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Target
Potassium-transporting ATPase alpha chain 1/subunit beta
Ligand
BDBM50018854
Substrate
n/a
Meas. Tech.
ChEMBL_75905 (CHEMBL689040)
IC50
130000±n/a nM
Citation
 Adelstein, GW; Yen, CH; Haack, RA; Yu, S; Gullikson, G; Price, DV; Anglin, C; Decktor, DL; Tsai, H; Keith, RH Substituted 2-[(2-benzimidazolylsulfinyl)methyl]anilines as potential inhibitors of H+/K+ ATPase. J Med Chem 31:1215-20 (1988) [PubMed]  Article 
Target
Name:
Potassium-transporting ATPase alpha chain 1/subunit beta
Synonyms:
Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1/beta chain
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 71495
Components:
This complex has 2 components.
Component 1
Name:
Potassium-transporting ATPase alpha chain 1
Synonyms:
ATP4A | ATP4A_HUMAN | Gastric H(+)/K(+) ATPase subunit alpha | Potassium-transporting ATPase | Potassium-transporting ATPase alpha chain 1 | Proton pump
Type:
PROTEIN
Mol. Mass.:
114109.05
Organism:
Homo sapiens (Human)
Description:
EBI_82
Residue:
1035
Sequence:
MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY
  
Component 2
Name:
Potassium-transporting ATPase subunit beta
Synonyms:
ATP4B | ATP4B_HUMAN | Gastric H(+)/K(+) ATPase subunit beta | Potassium-transporting ATPase | Potassium-transporting ATPase subunit beta | Proton pump beta chain
Type:
PROTEIN
Mol. Mass.:
33369.83
Organism:
Homo sapiens (Human)
Description:
EBI_10719
Residue:
291
Sequence:
MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLYVLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGYSPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFIIKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK
  
Inhibitor
Name:
BDBM50018854
Synonyms:
2-(Pyridin-2-ylmethanesulfinyl)-1H-benzoimidazole | 2-(Pyridin-2-ylmethanesulfinyl)-1H-benzoimidazole(timoprazole) | CHEMBL9861 | TIMOPRAZOLE
Type:
Small organic molecule
Emp. Form.:
C13H11N3OS
Mol. Mass.:
257.311
SMILES:
O=S(Cc1ccccn1)c1nc2ccccc2[nH]1
Structure:
Search PDB for entries with ligand similarity: