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Target
Probable L-lysine-epsilon aminotransferase
Ligand
BDBM50450914
Substrate
n/a
Meas. Tech.
ChEMBL_1744139 (CHEMBL4178649)
IC50
10380±n/a nM
Citation
 Reshma, RS; Jeankumar, VU; Kapoor, N; Saxena, S; Bobesh, KA; Vachaspathy, AR; Kolattukudy, PE; Sriram, D Mycobacterium tuberculosis lysine-?-aminotransferase a potential target in dormancy: Benzothiazole based inhibitors. Bioorg Med Chem 25:2761-2771 (2017) [PubMed]  Article 
Target
Name:
Probable L-lysine-epsilon aminotransferase
Synonyms:
2.6.1.36 | L-lysine aminotransferase | LAT_MYCTU | Lysine 6-aminotransferase | Probable L-lysine-epsilon aminotransferase | lat
Type:
PROTEIN
Mol. Mass.:
49007.52
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
ChEMBL_105536
Residue:
449
Sequence:
MAAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGSYLVDAITGRRYLDMFTFVASSALGMNPPALVDDREFHAELMQAALNKPSNSDVYSVAMARFVETFARVLGDPALPHLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQVLHLRGAFHGRSGYTLSLTNTKPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPIQGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLDVAPDIVAFGKKTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRDELIRQLWQRAVIVLPAGADTVRFRPPLTVSTAEIDAAIAAVRSALPVVT
  
Inhibitor
Name:
BDBM50450914
Synonyms:
CHEMBL4203644
Type:
Small organic molecule
Emp. Form.:
C16H10N2OS
Mol. Mass.:
278.328
SMILES:
Oc1ccc(\C=C(/C#N)c2nc3ccccc3s2)cc1
Structure:
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