Reaction Details
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5-hydroxytryptamine receptor 1A
Ligand
BDBM50451052
Substrate
n/a
Meas. Tech.
ChEMBL_1744656 (CHEMBL4179166)
Ki
53±n/a nM
Citation
Fiorino, F; Magli, E; K?dzierska, E; Ciano, A; Corvino, A; Severino, B; Perissutti, E; Frecentese, F; Di Vaio, P; Saccone, I; Izzo, AA; Capasso, R; Massarelli, P; Rossi, I; Orzelska-Gòrka, J; Kotli?ska, JH; Santagada, V; Caliendo, G New 5-HT Bioorg Med Chem 25:5820-5837 (2017) [PubMed] Article More Info.:
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
Inhibitor
Name:
BDBM50451052
Synonyms:
CHEMBL4210997
Type:
Small organic molecule
Emp. Form.:
C26H29ClF2N4O
Mol. Mass.:
486.984
SMILES:
Cl.Fc1ccc(cc1)C(N1CCN(CCCNC(=O)c2ccccn2)CC1)c1ccc(F)cc1
Structure:
