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Target
Cannabinoid receptor 1
Ligand
BDBM50451737
Substrate
n/a
Meas. Tech.
ChEMBL_1746156 (CHEMBL4180666)
IC50
180±n/a nM
Citation
 Bertini, S; Chicca, A; Gado, F; Arena, C; Nieri, D; Digiacomo, M; Saccomanni, G; Zhao, P; Abood, ME; Macchia, M; Gertsch, J; Manera, C Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor. Bioorg Med Chem 25:6427-6434 (2017) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50451737
Synonyms:
CHEMBL4206416
Type:
Small organic molecule
Emp. Form.:
C22H22ClN5O
Mol. Mass.:
407.896
SMILES:
Clc1ccc(NC(=O)Nc2cccc(Nc3cccc(n3)N3CCCC3)c2)cc1
Structure:
Search PDB for entries with ligand similarity: