Reaction Details Report a problem with these data
Target
Atrial natriuretic peptide receptor 1
Ligand
BDBM50452465
Substrate
n/a
Meas. Tech.
ChEMBL_1747592 (CHEMBL4182102)
EC50
530±n/a nM
Citation
 Iwaki, T; Tanaka, T; Miyazaki, K; Suzuki, Y; Okamura, Y; Yamaki, A; Iwanami, M; Morozumi, N; Furuya, M; Oyama, Y Discovery and in vivo effects of novel human natriuretic peptide receptor A (NPR-A) agonists with improved activity for rat NPR-A. Bioorg Med Chem 25:6680-6694 (2017) [PubMed]  Article 
Target
Name:
Atrial natriuretic peptide receptor 1
Synonyms:
4.6.1.2 | ANP-A | ANPR-A | ANPRA_RAT | Atrial natriuretic peptide receptor 1 | Atrial natriuretic peptide receptor type A | GC-A | Guanylate cyclase A | NPR-A | Npr1
Type:
PROTEIN
Mol. Mass.:
118956.96
Organism:
Rattus norvegicus
Description:
ChEMBL_18039
Residue:
1057
Sequence:
MPGSRRVRPRLRALLLLPPLLLLRGGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGERGCSTRG
  
Inhibitor
Name:
BDBM50452465
Synonyms:
CHEMBL4209251
Type:
Small organic molecule
Emp. Form.:
C27H35FN6O2
Mol. Mass.:
494.6042
SMILES:
CC(C)NC(=O)N[C@H]1CC[C@@H](CC1)Nc1nc(N[C@H](C)CO)nc2ccc(cc12)-c1cccc(F)c1 |r,wU:10.13,18.19,wD:7.6,(75.48,-29.25,;74.16,-28.48,;74.17,-26.95,;72.83,-29.24,;71.5,-28.47,;71.51,-26.94,;70.17,-29.23,;68.84,-28.45,;68.85,-26.91,;67.52,-26.13,;66.19,-26.89,;66.18,-28.43,;67.51,-29.21,;64.86,-26.12,;64.86,-24.58,;66.2,-23.81,;66.21,-22.27,;67.55,-21.51,;68.86,-22.28,;68.85,-23.8,;70.19,-21.53,;71.51,-22.3,;64.88,-21.5,;63.54,-22.26,;62.21,-21.49,;60.87,-22.25,;60.86,-23.79,;62.2,-24.57,;63.54,-23.8,;59.53,-24.55,;59.52,-26.09,;58.18,-26.85,;56.85,-26.08,;56.86,-24.54,;55.54,-23.77,;58.2,-23.77,)|
Structure:
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